抗うつ薬による院外心停止の危険性

デンマークにおける院外心停止(out-of-hospital cardiac arrest: OHCA)の全患者 were identified (2001-2007). Association between treatment with 特異的な抗うつ薬とOHCA の関連をcase-time-control modelの条件付ロジスティック回帰により調べた。19,110人の OHCA; 2,913人 (15.2%) がOHCAの際抗うつ薬内服中, citalopramが最も多い (50.8%)。三環系抗うつ薬TCA (TCAs; odds ratio (OR) = 1.69, confidence interval (CI): 1.14-2.50) とSSRI (SSRIs; OR = 1.21, CI: 1.00-1.47)がOHCAの危険性を高めるが、SNRIs/NaSSAsには関連なし (SNRIs/NaSSAs; OR = 1.06, CI: 0.81-1.39). citalopram(セレクサ:日本で使用不能のSSRI) (OR = 1.29, CI: 1.02-1.63) およびnortriptyline(ノリトレン) (OR = 5.14, CI: 2.17-12.2).

Clin Pharmacol Ther. 2012 May 16. doi: 10.1038/clpt.2011.368. [Epub ahead of print]
Antidepressant Use and Risk of Out-of-Hospital Cardiac Arrest: A Nationwide Case-Time-Control Study.
Weeke P, Jensen A, Folke F, Gislason GH, Olesen JB, Andersson C, Fosbøl EL, Larsen JK, Lippert FK, Nielsen SL, Gerds T, Andersen PK, Kanters JK, Poulsen HE, Pehrson S, Køber L, Torp-Pedersen C.
1] Department of Cardiology, Copenhagen University Hospital, Gentofte, Denmark [2] Department of Clinical Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
[PR]

by fibromyalgia11 | 2012-05-20 14:12 | 抗うつ薬
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世界標準の線維筋痛症を専門家が説明します


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