NSAID(非ステロイド性抗炎症薬)は脳卒中の危険因子


方法:研究開始時にthe Women's Healthy Studyの脳卒中やTIAの既往のない女性を前向きコホート研究でNSAID使用の脳卒中の機能への影響を調べた。研究の各年で女性をNSAID 非使用者 (過去1か月で11未満の使用), 使用者(前の月に11日以上使用), およびmissing ( NSAID使用に関する答えがない)に分類。機能的な結果は、0 to 1, 2 to 3, or 4 to 6のmodified Rankin scale (mRS) 点数で示したTIAまたは虚血性脳卒中。結果:平均で15.7年の経過観察後, 702のTIAs, mRS 0-1の292の虚血性脳卒中があり、mRS 2-3の虚血性の脳卒中が233 、mRS 4-6の虚血性脳卒中が98. NSAID非使用の女性に比べると, NSAID使用の女性は多変量で補正すると (95% CI) TIA は1.00 (0.77, 1.29), mRS 0-1は 1.48 (1.04, 2.10), mRS 2-3は0.83 (0.52, 1.33), mRS 4-6は1.33 (0.68, 2.59).まとめ:この大規模なコホート研究によるとNSAID使用は軽度の機能障害を持つ虚血性脳卒中の危険性が高くなることと関連することを示唆。
Eur J Intern Med. 2014 Feb 10. pii: S0953-6205(14)00015-6. doi: 10.1016/j.ejim.2014.01.013. [Epub ahead of print]
Non-steroidal anti-inflammatory drug use and functional outcome from ischemic cerebral events among women.
Rist PM1, Glymour MM2, Orav EJ3, Kim E4, Kase CS5, Buring JE6, Kurth T7.
•1Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States; Department of Epidemiology, Harvard School of Public Health, Boston, MA, United States; Department of Social and Behavioral Sciences, Harvard School of Public Health, Boston, MA, United States. Electronic address: prist@mail.harvard.edu
•2Department of Social and Behavioral Sciences, Harvard School of Public Health, Boston, MA, United States; Department of Epidemiology and Biostatistics, University of California-San Francisco, San Francisco, CA, United States.
•3Division of General Internal Medicine and Primary Care, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States; Department of Biostatistics, Harvard School of Public Health, Boston, MA, United States.
•4Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
•5Department of Neurology, Boston University School of Medicine, Boston, MA, United States.
•6Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States; Department of Epidemiology, Harvard School of Public Health, Boston, MA, United States.
•7Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States; Department of Epidemiology, Harvard School of Public Health, Boston, MA, United States; Inserm Research Center for Epidemiology and Biostatistics (U897), Bordeaux, France, Bordeaux, France; College of Health Sciences, University of Bordeaux, Bordeaux, France.
[PR]

by fibromyalgia11 | 2014-02-16 19:56 | アセトアミノフェン、NSAID
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