ムコスタの抗潰瘍効果


方法:継続的なNSAID治療が必要な479人の研究。患者は無作為に100 mg のrebamipideを1日3回又は200 μg のmisoprostolを1日3回、12週間に振分け。一次的な評価基準は12週間後に内視鏡で確認した胃潰瘍の発生率。結果:479人の患者のうち, 242人はrebamipid内服, そして237人misoprostol内服。最終的に, misoprostol 群では44人の患者 (18.6%)が脱落しrebamipideでは25人の患者(10.3%)が脱落. 脱落率には両群で有意差あり (p=0.0103). The per protocol analysis set was not valid because of the dropout rate of the misoprostol group; thus, 包括解析(intention to treat:ITT) analysis set is the main set for the efficacy analysis in this study. ITT解析によると、12週間後, 胃潰瘍の発生率はrebamipide群と misoprostol 群で同程度(20.3% vs 21.9%, p=0.6497).さらに, あまとめ:misoprostolの悪いコンプライアンスや副作用の可能性を考えると, rebamipideは臨床的に効果的で安全な選択肢の様だ。
Gut Liver. 2014 Jul;8(4):371-9. doi: 10.5009/gnl.2014.8.4.371. Epub 2013 Dec 24.
Preventive efficacy and safety of rebamipide in nonsteroidal anti-inflammatory drug-induced mucosal toxicity.
Kim JH1, Park SH1, Cho CS2, Lee ST3, Yoo WH4, Kim SK5, Kang YM6, Rew JS7, Park YW8, Lee SK9, Lee YC10, Park W11, Lee DH12.
•1Department of Gastroenterology, Yeouido St. Mary's Hospital, The Catholic University of Korea College of Medicine, Seoul, Korea.
•2Department of Rheumatology, Yeouido St. Mary's Hospital, The Catholic University of Korea College of Medicine, Seoul, Korea.
•3Department of Gastroenterology, Chonbuk National University Hospital, Chonbuk National University Medical School, Jeonju, Korea.
•4Department of Rheumatology, Chonbuk National University Hospital, Chonbuk National University Medical School, Jeonju, Korea.
•5Department of Gastroenterology, Kyungpook National University Hospital, Kyungpook National University School of Medicine, Daegu, Korea.
•6Department of Rheumatology, Kyungpook National University Hospital, Kyungpook National University School of Medicine, Daegu, Korea.
•7Department of Gastroenterology, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, Korea.
•8Department of Rheumatology, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, Korea.
•9Department of Rheumatology, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
•10Department of Gastroenterology, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
•11Department of Rheumatology, Inha University Hospital, Inha University School of Medicine, Incheon, Korea.
•12Department of Gastroenterology, Inha University Hospital, Inha University School of Medicine, Incheon, Korea.
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by fibromyalgia11 | 2014-08-03 22:39 | アセトアミノフェン、NSAID
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世界標準の線維筋痛症を専門家が説明します


by fibromyalgia11
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