向精神薬による全原因の死亡率


方法:5861人のパーキンソン病(PD)患者と年齢、性別、結婚状態でマッチさせた31,395人のPDではない対照群を同定し、1997年から2007年までの投薬と生死の状態の登録データを得た。結果:全原因の死亡率はPD患者と対照群において向精神薬の大部分で有意に高くなる。各薬ハザード比は以下の通り: SSRI又はSNRI, PD HR = 1.19, 95% CI = 1.04-1.36; Control HR = 1.77, 95% CI = 1.64-1.91;BZD, PD HR = 1.17, 95% CI = 0.99-1.38; Control HR = 1.39, 95% CI = 1.29-1.51; ベンゾジアゼピン様薬, PD HR = 1.33, 95% CI = 1.11-1.59; Control HR = 1.27, 95% CI = 1.18-1.37; 第一世代の抗精神病薬, PD HR = 1.89, 95% CI = 1.42-2.53; Control HR = 2.12, 95% CI = 1.82-2.47; 第二世代の抗精神病薬, PD HR = 1.46, 95% CI = 1.20-1.76; Control HR = 2.00, 95% CI 1.66-2.43; そして、治療を受けていないPDおよび対照群に比較したこれらの薬の併用。両群とも薬を中止すると死亡率は低下する。
Parkinsonism Relat Disord. 2014 Aug 1. pii: S1353-8020(14)00272-7. doi: 10.1016/j.parkreldis.2014.07.012. [Epub ahead of print]
Increased all-cause mortality with psychotropic medication in Parkinson's disease and controls: A national register-based study.
Frandsen R1, Baandrup L2, Kjellberg J3, Ibsen R4, Jennum P5.
•1Danish Center for Sleep Medicine, Department of Clinical Neurophysiology, Copenhagen University Hospital, Glostrup, Denmark.
•2Center for Neuropsychiatric Schizophrenia Research & Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research, Mental Health Center Glostrup, Copenhagen University Hospital, Glostrup, Denmark.
•3Danish Institute for Health Services Research, Copenhagen, Denmark.
•4iTracks, Klosterport 4E, 4, Aarhus, Denmark.
•5Danish Center for Sleep Medicine, Department of Clinical Neurophysiology, Copenhagen University Hospital, Glostrup, Denmark; Center for Healthy Aging, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark. Electronic address: poul.jennum@regionh.dk.
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by fibromyalgia11 | 2014-09-01 23:46 | 抗うつ薬
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世界標準の線維筋痛症を専門家が説明します


by fibromyalgia11
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