むずむず脚症候群に対する感覚運動野への経頭蓋直接電気刺激


経頭蓋直接電気刺激(transcranial direct current stimulation:tDCS) で薬物治療を受けていないRLS患者への効果を評価。方法:2週間の、二重盲検、無作為振り分け、偽刺激対照の研究。33人のRLS女性。参加者は陰極、陽極を用いた5回のtDCSセッションを受けるか偽刺激を受ける。治療前 (T0), t tDCS 終了の3日後(T1) そして13日後(T2)に評価。一次的な結果にはthe International RLS Group Rating Scale (IRLS) およびthe Clinical Global Impressions-Improvement (CGI-I)を含む。二次的な結果にはthe Patient Global Impression scale, the Pittsburgh Sleep Quality Index, the Medical Outcome Study sleep subscales, およびthe Beck Depression Inventoryを含む。客観的な神経生理学的な変化はEEGのevent-related desynchronization/synchronization (ERD/ERS)を用いて評価。結果:両群でIRLS点数の変化, the CGI-I scaleでの反応率, には有意差はない。二次的な結果やERD/ERSにも両群で有意差はない。結果:感覚運動野への経頭蓋直接電気刺激は薬を飲んでいないRLS患者には有意な効果はない。
Sleep Med. 2014 Dec 2. pii: S1389-9457(14)00472-9. doi: 10.1016/j.sleep.2014.07.032. [Epub ahead of print]
Transcranial direct current stimulation on primary sensorimotor area has no effect in patients with drug-naïve restless legs syndrome: a proof-of-concept clinical trial.
Koo YS1, Kim SM1, Lee C2, Lee BU2, Moon YJ2, Cho YW3, Im CH4, Choi JW5, Kim KH5, Jung KY6.
•1Department of Neurology, Korea University Medical Center Anam Hospital, Korea University College of Medicine, Seoul, South Korea.
•2Department of Neurology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South Korea.
•3Department of Neurology, Dongsan Medical Center, Keimyung University School of Medicine, Daegu, South Korea.
•4Department of Biomedical Engineering, Hanyang University, Seoul, South Korea.
•5Department of Biomedical Engineering, College of Health Science, Yonsei University, Wonju, Gangwon-do, South Korea.
•6Department of Neurology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South Korea. Electronic address: jungky10@gmail.com.
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by fibromyalgia11 | 2015-01-18 22:25 | むずむず脚症候群
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世界標準の線維筋痛症を専門家が説明します


by fibromyalgia11
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