抗うつ薬のメタ解析には製薬会社の利益が影響する


MEDLINEを用いて, 1/2007-3/2014の間に出版された抑うつに対する抗うつ薬を評価したメタ解析を同定。著者の所属, 利益相反および、抗うつ薬が有効かどうか安全かどうかに関する負の声明をアブストラクトのまとめが含むかどうかに関するデータを抽出。結果:185の的確なメタ解析を同定。 54 (29%)のメタ解析は、著者が評価された薬の製薬会社の従業員であり147 (79%)は製薬会社と何らかの関係あり (財政支援又は著者が製薬会社の従業員and/or利益相反あり)。58のメタ解析のみ (31%)アブストラクトのまとめの声明で負の声明.評価された薬の製薬会社の従業員を著者に含むメタ解析はその他のメタ解析よりも22倍負の声明をしにくい (1/54 [2%] vs. 57/131 [44%], p<0.001).
J Clin Epidemiol. 2015 Sep 20. pii: S0895-4356(15)00429-1. doi: 10.1016/j.jclinepi.2015.08.021. [Epub ahead of print]
Meta-analyses with industry involvement are massively published and report no caveats for antidepressants.
Ebrahim S1, Bance S2, Athale A3, Malachowski C4, Ioannidis JP5.
•1Stanford Prevention Research Center, Department of Medicine, 1265 Welch Road, 3rd floor, Stanford University, Stanford, CA 94305, USA; Meta-Research Innovation Center at Stanford (METRICS), Stanford University, 1265 Welch Rd, Stanford, CA 94305, USA; Department of Clinical Epidemiology & Biostatistics, 1200 Main Street West, Room 2C, McMaster University, Hamilton, Ontario, Canada, L8S 4K1; Department of Anesthesia, 1200 Main Street West, HSC 2U1, McMaster University, Hamilton, Ontario, Canada, L8S 4K1; Department of Anaesthesia and Pain Medicine, 555 University Ave, Hospital for Sick Children, Toronto, Ontario, Canada, M5G 1X8.
•2Department of Applied Psychology and Human Development, Ontario Institute for Studies in Education, 252 Bloor Street West, University of Toronto, Toronto, Ontario, Canada, M5S 1V6.
•3Department of Rehabilitation Science, 500 University Ave, University of Toronto, Toronto, Ontario Canada, M5G 1V7.
•4Department of Health Research and Policy, Redwood Building T152, 150 Governor's Lane, Stanford University School of Medicine, Stanford, California, United States of America, 94305.
•5Stanford Prevention Research Center, Department of Medicine, 1265 Welch Road, 3rd floor, Stanford University, Stanford, CA 94305, USA; Meta-Research Innovation Center at Stanford (METRICS), Stanford University, 1265 Welch Rd, Stanford, CA 94305, USA; Department of Health Research and Policy, Redwood Building T152, 150 Governor's Lane, Stanford University School of Medicine, Stanford, California, United States of America, 94305; Department of Statistics, 390 Serra Mall, Stanford University School of Humanities and Sciences, Stanford, CA 94305, USA. Electronic address: jioannid@stanford.edu.
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by fibromyalgia11 | 2015-09-29 08:41 | 抗うつ薬
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世界標準の線維筋痛症を専門家が説明します


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