NSAIDとアスピリンによる胃腸合併症

南イタリアの自発的な薬の副作用(adverse drugreactionsADRs) 報告システムを解析することにより、実際の生活の状況でのNSAIDs およびアセチルサリチル酸(acetylsalicylicacidLDA)の単独治療またはその併用治療としての胃腸(GastrointestinalGI)安全性のプロフィールを調べる。イタリアの医薬品の副作用調査ネットワーク(PharmacovigilanceNetworkRNF)の症例/非症例法を用いた.症例は20071月からDecember201112までにRNFGIの出来事の報告。年齢および抗癌剤又は心血管疾患の薬の併用使用で補正して非比例の計測として、非症例は同じ期間のその他のすべての症例。報告されたオッズ比(reportingodds ratioROR) 95%信頼区間を用いて、NSAIDと推定されたGI ADRsの関連を計算した。NSAIDクラスの中でサブ解析を行った.薬の副作用を報告した 2,816例の中で,374 (13.3%)GI合併症. 上部GI合併症は最も頻度が多い合併症. NSAIDs and/or LDAの併用使用で最も関連が高いが,各単独両方では関連が最も低い。各NSAIDsを調べると、GIの出来事が最も高い薬はketorolac 次いでnimesulide,diclofenac, aspirin, ketoprofen, およびibuprofen.

Pharmacol Res.2015 Dec 28. pii: S1043-6618(15)30072-4. doi: 10.1016/j.phrs.2015.12.026. [Epubahead of print]

Risk of gastrointestinal complicationsassociated to NSAIDs, low-dose aspirin and their combinations: results of aregional spontaneous reporting system.

Rafaniello C1, Ferrajolo C2, Sullo MG3, Sessa M4, Sportiello L5, Balzano A6, Manguso F7, Aiezza ML8, Rossi F9, Scarpignato C10, Capuano A9.

  • 1Department of Experimental Medicine, Section of Pharmacology "L. Donatelli", Second University of Naples, via de Crecchio 7, 80138 Naples, Italy. Electronic address: concita.rafaniello@gmail.com.
  • 2Department of Experimental Medicine, Section of Pharmacology "L. Donatelli", Second University of Naples, via de Crecchio 7, 80138 Naples, Italy. Electronic address: carmen.ferrajolo@unina2.it.
  • 3Department of Experimental Medicine, Section of Pharmacology "L. Donatelli", Second University of Naples, via de Crecchio 7, 80138 Naples, Italy. Electronic address: pina.sullo@libero.it.
  • 4Department of Experimental Medicine, Section of Pharmacology "L. Donatelli", Second University of Naples, via de Crecchio 7, 80138 Naples, Italy. Electronic address: maurizio_sessa@hotmail.it.
  • 5Department of Experimental Medicine, Section of Pharmacology "L. Donatelli", Second University of Naples, via de Crecchio 7, 80138 Naples, Italy. Electronic address: liberata.sportiello@unina2.it.
  • 6Gastroenterology Dept Cardarelli Hospital Naples, Via Antonio Cardarelli 9, 80131 Naples, Italy. Electronic address: balzano.antonio@hotmail.com.
  • 7Gastroenterology Unit, Cardarelli Hospital, Via Antonio Cardarelli 9, 80131 Naples, Italy. Electronic address: manguso@alice.it.
  • 8Complex Operating Unit of Pharmacy, AORN A Cardarelli, Via Antonio Cardarelli, 9, 80131 Naples Italy. Electronic address: marialuisa.aiezza@aocardarelli.it.
  • 9Department of Experimental Medicine, Section of Pharmacology "L. Donatelli", Second University of Naples, via de Crecchio 7, 80138 Naples, Italy.
  • 10Clinical Pharmacology & Digestive Pathophysiology Unit, Department of Clinical & Experimental Medicine, University of Parma, Via Volturno 39, 43100 Parma, Italy. Electronic address: scarpi@tin.it.

[PR]

by fibromyalgia11 | 2016-01-11 19:37 | アセトアミノフェン、NSAID
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