むずむず脚症候群患者は骨密度が多い

方法:薬を飲んでいないRLSおよび年齢とBMIをマッチさせた女性対照群の前向き、横断、症例対照研究. 通常の血液検査, 骨形成マーカーであるprocollagen 1 n-terminalpeptide, 骨吸収マーカーであるc-telopeptide of type 1 collagen(CTX), sclerostin,および骨密度(bone mineral densityBMD) を両群で比較。妊娠又は授乳女性、鉄欠乏性貧血、2型糖尿病、又は高血圧以外の合併症は除外。結果:78 人のRLS患者は78人の年齢BMIをマッチさせた対照群に比べて、腰椎のBMDが有意に増加(p = 0.001).腰椎のT scoreで定義した骨減少症の患者の割合はRLS患者の方が有意に低い (p = 0.040). CTX およびsclerostin RLS患者の方が有意に低い (各々p = 0.006 and p = 0.011), 25-hydroxyvitamin D3,calcemia, およびfree T3も同様 (各々p = 0.017, p = 0.017, and p = 0.002)。まとめ: 25-hydroxy vitamin D3が低いにもかかわらず、RLS患者は 骨吸収マーカーが低く,腰のBMDが高く,腰椎の骨減少症の頻度が低い. RLS患者は症状を軽減するために夜間と日中に動くために, 無意識に運動を行い、それがRLS患者は対照群よりも骨の状態が良好であることを説明できるかもしれない。

Neurology. 2016 Feb 26. pii:10.1212/WNL.0000000000002521. [Epub ahead of print]

Reduced bone resorption and increased bonemineral density in women with restless legs syndrome.

Cikrikcioglu MA1, Sekin Y2, Halac G2, Kilic E2, Kesgin S2, Aydin S2, Ozaras N2, Akan O2, Celik K2, Hamdard J2, Zorlu M2, Karatoprak C2, Cakirca M2, Kiskac M2.

  • 1From the Departments of Internal Medicine (M.A.C., Y.S., K.C., J.H., M.Z., C.K., M.C., M.K.), Neurology (G.H.), Biochemistry (E.K., S.K.), and Physical Medicine and Rehabilitation (N.O.), Bezmialem Vakif University Medical Faculty, Fatih; Department of Neurology (S.A.), Yedikule Chest Diseases and Chest Surgery Training and Research Hospital, Zeytinburnu; and Department of Neurology (O.A.), Okmeydani Training and Research Hospital, Sisli, Istanbul, Turkey. malicikrikcioglu@yahoo.com.
  • 2From the Departments of Internal Medicine (M.A.C., Y.S., K.C., J.H., M.Z., C.K., M.C., M.K.), Neurology (G.H.), Biochemistry (E.K., S.K.), and Physical Medicine and Rehabilitation (N.O.), Bezmialem Vakif University Medical Faculty, Fatih; Department of Neurology (S.A.), Yedikule Chest Diseases and Chest Surgery Training and Research Hospital, Zeytinburnu; and Department of Neurology (O.A.), Okmeydani Training and Research Hospital, Sisli, Istanbul, Turkey.

[PR]

by fibromyalgia11 | 2016-03-07 19:54 | むずむず脚症候群
line

世界標準の線維筋痛症を専門家が説明します


by fibromyalgia11
line