スタチンの抗うつ効果:メタ解析


スタチンが抑うつに有効かどうかの、無作為振り分け、二重盲検、偽薬対照研究のメタ解析。3つの研究が中等度から強度の抑うつのある165人の患者のデータを含む.そのうち, 82人は抗うつ治療(つまりcitalopram又はfluoxetine)に対して補助的なスタチンに無作為に振り分けられ83人は偽薬治療. すべての研究は二重盲検RCTsであり, 612週の経過観察.lovastatin, atorvastatin, およびsimvastatinのスタチンを評価. 偽薬と比較すると, 追加治療としてのstatins, HDRSにより評価した抑うつ症状を大きく改善した (SMD=-0.73, 95% IC -1.04 to -0.42, p<0.001,3 between-group comparisons, n=165).深刻な副作用は報告されず。


J Affect Disord. 2016 Apr27;200:235-242. doi: 10.1016/j.jad.2016.04.047. [Epub ahead of print]


Statins for the treatment of depression: Ameta-analysis of randomized, double-blind, placebo-controlled trials.


Salagre E1, FernandesBS2, Dodd S3, BrownsteinDJ4, Berk M5.


  • 1Deakin University, IMPACT Strategic Research Centre, School of Medicine, and Barwon Health, Geelong, Australia; Hospital de la Santa Creu i Sant Pau, Servei de Psiquiatria, Barcelona, Spain. Electronic address: esalagre@gmail.com.
  • 2Deakin University, IMPACT Strategic Research Centre, School of Medicine, and Barwon Health, Geelong, Australia; Laboratory of Calcium Binding Proteins in the Central Nervous System, Department of Biochemistry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil. Electronic address: brisasf@gmail.com.
  • 3Deakin University, IMPACT Strategic Research Centre, School of Medicine, and Barwon Health, Geelong, Australia; Department of Psychiatry, University of Melbourne, Parkville, Australia.
  • 4Monash University, Faculty of Medicine, Nursing and Health Sciences, Melbourne, Australia.
  • 5Deakin University, IMPACT Strategic Research Centre, School of Medicine, and Barwon Health, Geelong, Australia; Florey Institute for Neuroscience and Mental Health, Department of Psychiatry and Orygen, The National Centre of Excellence in Youth Mental Health, University of Melbourne, Parkville, Australia.



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by fibromyalgia11 | 2016-05-09 19:46 | その他
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世界標準の線維筋痛症を専門家が説明します


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