セルトラリン(ジェイゾロフト)による先天異常の危険性

Sertralineを第一三分期に使用すると先天異常の危険性が増えるかどうかというコホート研究の系統的総説とメタ解析。結果: 6,468,241人の妊婦を含む12のコホート研究を含む。random-effects modelを用いた先天異常のオッズ比(ORs)と95%信頼区間(CIs)をまとめた.Sertralineを第一三分期に使用した妊婦は、子供の心血管に関連した先天異常 (summarizedOR = 1.36; 95%CI = 1.06-1.74; I2  = 64.4%; n = 12) および心房and/or 心室中隔欠損(summarizedOR = 1.36, 95%CI = 1.06-1.76; I2  = 62.2%; n = 8)の危険性が有意に増加.さらに,sertraline使用と神経系(summarizedOR = 1.39; 95%CI = 0.83-2.32; I2  = 0%; n = 5),消化管 (summarized OR = 1.23; 95%CI = 0.76-1.98; I2  = 0%;n = 5), 目、耳、顔面および頸 (summarizedOR = 1.08; 95%CI = 0.33-3.55; I2  = 32.1%; n = 3), 泌尿生殖器系(summarized OR = 1.03;95%CI = 0.73-1.46; I2  = 0%; n = 5), および筋骨格系 (summarized OR = 0.97;95%CI = 0.69-1.36; I2  = 0%; n = 5)の先天異常には正のしかし非有意な関連が見られた.

Br J Clin Pharmacol. 2016 Oct22. doi: 10.1111/bcp.13161. [Epub ahead of print]

Sertraline use in the first trimester and riskof congenital anomalies: a systemic review and meta-analysis of cohort studies.

Shen ZQ1, Gao SY2, Li SX3, Zhang TN4, Liu CX1, Lv HC5, Zhang Y6, Gong TT1, Xu X2, Ji C2, Wu QJ7, Li D8.

  • 1Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China, (Z-QS, C-XL, T-TG, and DL).
  • 2Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, China, (S-YG, XX, CJ, and Q-JW).
  • 3International Education College, China Medical University, Shenyang, China, (SXL).
  • 4Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, China, (T-NZ).
  • 5Department of Cardiology, First Affiliated Hospital of Dalian Medical University, Dalian, China, (H-CL).
  • 6Department of Emergency, Shengjing Hospital of China Medical University, Shenyang, China, (YZ).
  • 7Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, China, (S-YG, XX, CJ, and Q-JW). wuqj@sj-hospital.org.
  • 8Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China, (Z-QS, C-XL, T-TG, and DL). leeda@sina.cn.


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