ベンゾジアゼピン系抗不安薬とZ-drugによる股関節骨折の系統的総説とメタ解析

Benzodiazepine (BNZ)z-drugの股関節骨折の危険性の系統的総説とメタ解析。BNZ,およびZ-drugは各々股関節骨折の危険性の増加と有意に関連 (RR = 1.52,95% CI 1.37-1.68; およびRR = 1.90,95% CI 1.68-2.13). 短期間のBNZ およびZ-drugsの使用は各々股関節骨折の危険性の増加と有意に関連 (RR = 2.40, 95% CI 1.88-3.05 およびRR = 2.39, 95% CI 1.74-3.29)。まとめ:高齢者においてBNZおよび Z-drugsの両方は股関節骨折の危険性の増加と関連し、それらにはほとんど差がない。新たに処方された薬は股関節骨折の危険性が最も高い。

PLoS One. 2017 Apr27;12(4):e0174730. doi: 10.1371/journal.pone.0174730. eCollection 2017.

Benzodiazepines, Z-drugsand the risk of hip fracture: A systematic review and meta-analysis.

DonnellyK1,2, Bracchi R1, Hewitt J2, RoutledgePA1, Carter B2,3,4.

1

Pharmacology,Therapeutics and Toxicology, Cardiff University School of Medicine, AcademicCentre, University Hospital Llandough, Cardiff, United Kingdom.

2

Institute ofPrimary Care and Public Health, Cardiff University, School of Medicine, NeuaddMeirionnydd, Cardiff, United Kingdom.

3

Departmentof Biostatistics and Health Informatics, Institute of Psychiatry, Psychologyand Neuroscience, King's College London, London, United Kingdom.

4

CochraneSkin Group, School of Medicine, The University of Nottingham, Nottingham,United Kingdom.



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