ガバペンチンはオピオイド関連の死亡を増加させる

人口に基づいたnestedcase-control study。多変量解析を行うと、opioid のみの処方に比べると、opioids gabapentinの併用はopioid関連死亡のオッズを有意に増加させる (odds ratio [OR] 1.99,95% CI 1.61 to 2.47, p < 0.001; adjusted OR [aOR] 1.49, 95% CI 1.18 to 1.88,p < 0.001).

PLoS Med. 2017 Oct3;14(10):e1002396. doi: 10.1371/journal.pmed.1002396. eCollection 2017 Oct.

Gabapentin, opioids, and the risk ofopioid-related death: A population-based nested case-control study.

Gomes T1,2,3,4, JuurlinkDN2,3,5,6, AntoniouT1,2,7, MamdaniMM1,2,3,4,6,8, PatersonJM2,3,9, van denBrink W10.

1

Li Ka ShingKnowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada.

2

Institutefor Clinical Evaluative Sciences, Toronto, Ontario, Canada.

3

Institute ofHealth Policy, Management and Evaluation, University of Toronto, Toronto,Ontario, Canada.

4

Leslie DanFaculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada.

5

SunnybrookResearch Institute, Toronto, Ontario, Canada.

6

Departmentof Medicine, University of Toronto, Toronto, Ontario, Canada.

7

Departmentof Family and Community Medicine, University of Toronto, Toronto, Ontario,Canada.

8

Departmentof Medicine, St. Michael's Hospital, Toronto, Ontario, Canada.

9

Departmentof Family Medicine, McMaster University, Hamilton, Ontario, Canada.

10

Departmentof Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, TheNetherlands.



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世界標準の線維筋痛症を専門家が説明します


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