妊娠中の酸抑制薬は子供の喘息の危険因子

妊娠中の酸抑制薬と子供時代の喘息の危険性のメタ解析。556の論文を選別し、8つの人口に基づいた研究を最終的に解析。全ての研究を統合すると、妊娠中の酸抑制薬の使用は子供時代の喘息の危険性を増加させる(relative risk [RR] = 1.45; 95%信頼区間 [CI] 1.35-1.56; I2= 0%; P < .00001). 子供時代の喘息の全般的な危険性はPPI使用者(RR = 1.34; 95% CI 1.18-1.52; I2= 46%; P < .00001)および histamine-2 receptor 阻害薬使用者(RR= 1.57; 95% CI 1.46-1.69; I2= 0%; P < .00001)で増加.

Pediatrics. 2018 Jan 11. pii:e20170889. doi: 10.1542/peds.2017-0889. [Epub ahead of print]

Acid-Suppressive DrugUse During Pregnancy and the Risk of Childhood Asthma: A Meta-analysis.

Lai T1,2,Wu M1,Liu J1,3,Luo M1,He L1,Wang X1,Wu B2,Ying S1,Chen Z1,Li W1,Shen H4,5.

1

Departmentof Respiratory and Critical Care Medicine, Second Affiliated Hospital,Institute of Respiratory Diseases, School of Medicine, Zhejiang University,Zhejiang Sheng, China.

2

Departmentof Respiratory and Critical Care Medicine, Institute of Respiratory Diseases,The Affiliated Hospital of Guangdong Medical University, Guangdong Sheng,China.

3

Instituteof Lung Biology and Disease, Helmholtz Zentrum München, German Center for LungResearch, Oberschleißheim, Germany; and.

4

Departmentof Respiratory and Critical Care Medicine, Second Affiliated Hospital,Institute of Respiratory Diseases, School of Medicine, Zhejiang University,Zhejiang Sheng, China; huahaoshen@zju.edu.cn.

5

StateKey Laboratory of Respiratory Diseases, Guangzhou Medical University,Guangzhou, China.



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