転倒の危険性を増やす向精神薬:系統的総説とメタ解析

参加者が60歳以上又は平均年齢が70歳以上の研究における向精神薬(抗精神病薬、抗うつ薬、抗不安薬、鎮静薬、睡眠薬)の転倒の危険性の系統的総説とメタ解析。結果:248の研究が定性的な統合に含める基準に合致。補正したデータを用いたメタ解析によると以下のような統合されたORs: 抗精神病薬1.54 [95%信頼区間(CI) 1.28-1.85], 抗うつ薬1.57 (95% Cl1.43-1.74), TCA 1.41 (95% CI 1.07-1.86), SSRI 2.02 (95% CI 1.85-2.20), benzodiazepines 1.42 (95%, CI 1.22-1.65), 長期作用型benzodiazepines 1.81 (95%,CI 1.05-3.16),および短期作用型benzodiazepines 1.27 (95%,CI 1.04-1.56) メタ解析の大部分は人口および医療の場の層化後には消えてなくならないかなりの異質性の結果になる.

J Am MedDir Assoc. 2018 Feb 2. pii: S1525-8610(17)30784-3. doi:10.1016/j.jamda.2017.12.098. [Epub ahead of print]

Fall-Risk-Increasing Drugs: A Systematic Reviewand Meta-Analysis: II. Psychotropics.

SeppalaLJ1, WermelinkAMAT1, de VriesM1, PloegmakersKJ1, van deGlind EMM1, Daams JG2, van derVelde N3; EUGMStask and Finish group on fall-risk-increasing drugs.

Collaborators(21)

Blain H, BousquetJ,Bucht G, Caballero-MoraMA,van derCammen T, Eklund P, Emmelot-VonkM,GustafsonY,HartikainenS,Kenny RA, LaflammeL,Landi F, Masud T, O'Byrne-MaguireI,PetrovicM,RodriguezL,Seppälä L, SvenssonO,SzczerbińskaK,Thaler H, van derVelde N.

1

Departmentof Internal Medicine, Section of Geriatric Medicine, Academic Medical Center,University of Amsterdam, Amsterdam, The Netherlands; Amsterdam Public HealthResearch Institute, Amsterdam, The Netherlands.

2

MedicalLibrary, Academic Medical Center, Amsterdam, The Netherlands.

3

Departmentof Internal Medicine, Section of Geriatric Medicine, Academic Medical Center,University of Amsterdam, Amsterdam, The Netherlands; Amsterdam Public HealthResearch Institute, Amsterdam, The Netherlands. Electronic address:n.vandervelde@amc.uva.nl.


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