重篤な精神疾患患者での死亡の危険因子

方法:統合失調症(n = 789) および双極性障害 (n = 498)患者, mean ageof 38 (s.d. 12.6) years, underwent an in-person clinical assessment. They alsohad a blood sample drawn from which infectious disease markers were measured.Mortality was subsequently determined utilizing data from the National DeathIndex following a period of up to 16.9 years.結果:A total of6.8% (87 of 1287) of persons died of natural causes. 多変量モデルによると死亡率は以下で予測される:ベースラインの喫煙(RR = 6.29,95% CI 1.41, 3.72, P = 0.00076); 離婚または死別状態 (RR = 1.90, CI 1.21, 2.99); 認知点数の低下(RR = 0.73,CI 0.61, 0.87); 抗うつ薬使用 (RR = 1.74,CI 1.12, 2.71); Epstein-Barr virus (EBV) に対する抗体価の増加(RR = 1.29, CI 1.01, 1.66); および泌尿生殖器症状(RR = 1.82,CI 1.16, 2.86), 呼吸器症状(RR = 1.82,CI 1.16, 2.86), 又は心臓症状(RR = 2.09,CI 1.33, 3.29)。喫煙および心臓症状や呼吸器症状には相加効果があるが EBV 抗体価の増加はそうではない.

Acta Psychiatr Scand. 2018 Mar30. doi: 10.1111/acps.12880. [Epub ahead of print]

Natural cause mortality in persons with seriousmental illness.

DickersonF1, Origoni A1, SchroederJ2, Adamos M3, KatsafanasE1, KhushalaniS1, SavageCLG4, SchweinfurthLAB1, StallingsC1, Sweeney K1, Yolken R5.

1

StanleyResearch Program, Sheppard Pratt Health System, Baltimore, MD, USA.

2

SchroederStatistical Consulting, Ellicott City, MD, USA.

3

CongruentCounseling Services, Columbia, MD, USA.

4

Departmentof Psychology, University of Maryland, College Park, MD, USA.

5

Departmentof Pediatrics, Johns Hopkins School of Medicine, Baltimore, MD, USA.



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by fibromyalgia11 | 2018-04-03 20:00 | 複合性局所疼痛症候群
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