抗うつ薬による認知機能障害:メタ解析
抗うつ薬による認知機能低下の危険性増加の観察研究のメタ解析。9 つの研究のうち5つは53,955人の参加者があり、含める基準に合致。認知症の全般的な統合したRRはSSRIsでは1.75 (95% CI: 1.033-2.964) 、TCAでは2.131 (95% CI: 1.427-3.184). MAOIsは著しい異質性があり高い危険性.
BehavNeurol.2018 Jul 10;2018:5315098. doi: 10.1155/2018/5315098. eCollection 2018.
Increased Risk of Dementia in Patientswith Antidepressants: A Meta-Analysis of Observational Studies.
Wang YC1,2,3, Tai PA4, Poly TN1,3, Islam MM1,3, Yang HC1,4, Wu CC1,3, Li YJ1,3,5,6.
1
Graduate Institute of Biomedical Informatics,College of Medical Science and Technology, Taipei Medical University, Taipei,Taiwan.
2
Department of Emergency, Min-Sheng GeneralHospital, Taoyuan City, Taiwan.
3
International Center for Health InformationTechnology (ICHIT), Taipei Medical University, Taipei, Taiwan.
4
Department of Surgery, School of Medicine,Buddhist Tzu Chi University, Hualien, Taiwan.
5
Department of Dermatology, Wan Fang Hospital,Taipei, Taiwan.
6
TMU Research Center of Cancer TranslationalMedicine, Taipei, Taiwan.