プロトンポンプ阻害薬は中枢神経系の感染を引き起こしやすい
大規模な後ろ向きコホート研究。PPI使用者は非使用者よりも中枢神経系の感染の発生が2.23倍(95%CI = 1.27⁻3.94)高い。高血圧とCharlson comorbidity index (CCI)= 1の群 (各々aHR= 3.80, 95% CI = 1.40⁻10.32;aHR = 2.47, 95% CI = 1.07⁻5.70in the PPI)ではPPI使用者は非使用者よりも中枢神経系の感染の危険性が高い.
J Clin Med.2018 Aug 31;7(9). pii: E252. doi: 10.3390/jcm7090252.
Association between Proton Pump Inhibitor Use and CNS Infection Risk: ARetrospective Cohort Study.
Hung WT1,2,3,Teng YH4,5,Yang SF6,7,Yeh HW8,Yeh YT9,10,11,Wang YH12,Chou MY13,14,Chou MC15,Chan CH16,17,Yeh CB18,19.
1
Instituteof Medicine, Chung Shan Medical University, Taichung 40201, Taiwan.cshy029@csh.org.tw.
2
Schoolof Medicine, Chung Shan Medical University, Taichung 40201, Taiwan.cshy029@csh.org.tw.
3
Departmentof Anesthesiology, Chung Shan Medical University Hospital, Taichung 40201,Taiwan. cshy029@csh.org.tw.
4
Departmentof Emergency Medicine, School of Medicine, Chung Shan Medical University,Taichung 40201, Taiwan. cshy392@csh.org.tw.
5
Departmentof Emergency Medicine, Chung Shan Medical University Hospital, Taichung 40201,Taiwan. cshy392@csh.org.tw.
6
Instituteof Medicine, Chung Shan Medical University, Taichung 40201, Taiwan.ysf@csmu.edu.tw.
7
Departmentof Medical Research, Chung Shan Medical University Hospital, Taichung 40201,Taiwan. ysf@csmu.edu.tw.
8
Schoolof Medicine, Chang Gung University, Taoyuan City 33302, Taiwan.george66889@gmail.com.
9
GraduateSchool of Dentistry, Chung Shan Medical University, Taichung 40201, Taiwan.yehtungtung@hotmail.com.
10
Schoolof Dentistry, Chung Shan Medical University, Taichung 40201, Taiwan.yehtungtung@hotmail.com.
11
Departmentof Dentistry, Chung Shan Medical University Hospital, Taichung 40201, Taiwan.yehtungtung@hotmail.com.
12
Departmentof Medical Research, Chung Shan Medical University Hospital, Taichung 40201,Taiwan. cshe731@csh.org.tw.
13
Schoolof Dentistry, Chung Shan Medical University, Taichung 40201, Taiwan.myc@csmu.edu.tw.
14
Departmentof Dentistry, Chung Shan Medical University Hospital, Taichung 40201, Taiwan.myc@csmu.edu.tw.
15
Instituteof Medicine, Chung Shan Medical University, Taichung 40201, Taiwan.mcchou@gmail.com.
16
Departmentof Medical Research, Chung Shan Medical University Hospital, Taichung 40201,Taiwan. chiho@csmu.edu.tw.
17
Departmentof Microbiology and Immunology, Chung Shan Medical University, Taichung 40201,Taiwan. chiho@csmu.edu.tw.
18
Departmentof Emergency Medicine, School of Medicine, Chung Shan Medical University,Taichung 40201, Taiwan. sky5ff@gmail.com.
19
Departmentof Emergency Medicine, Chung Shan Medical University Hospital, Taichung 40201,Taiwan. sky5ff@gmail.com.