プロトンポンプ阻害薬は心血管イベントを増加させる
イタリアの一般人口におけるPPI使用による虚血性イベントの危険性。症例対照研究。脳血管イベントの危険性は現在(OR 1.61; 95%CI 1.55-1.68) および最近の使用者(OR 1.15; 95%CI 1.06-1.26)では過去の使用者に比べると有意に高い 。心血管イベント(ORcurrent 1.71;95%CI 1.63-1.81)および脳血管イベント(ORcurrent1.43; 95%CI 1.34-1.54)で階層化しても同様の結果. 抗血栓薬とスタチン使用、又は暴露期間のサブグループでも危険性増加.同様の解析ではH2-antagonists使用では有意な結果にはならず.
Atherosclerosis. 2018Aug 27;277:123-129. doi: 10.1016/j.atherosclerosis.2018.08.035. [Epub ahead ofprint]
Use of proton pump inhibitors and risk of ischemic events inthe general population.
Casula M1,Scotti L2,Galimberti F3,Mozzanica F3,Tragni E3,Corrao G2,Catapano AL4.
1
Epidemiologyand Preventive Pharmacology Centre (SEFAP), Department of Pharmacological andBiomolecular Sciences, University of Milan, Via Balzaretti 9, 20133, Milan,Italy. Electronic address: manuela.casula@unimi.it.
2
Departmentof Statistics and Quantitative Methods, Division of Biostatistics, Epidemiologyand Public Health, University of Milano-Bicocca, Via Bicocca degli Arcimboldi8, 20126, Milan, Italy.
3
Epidemiologyand Preventive Pharmacology Centre (SEFAP), Department of Pharmacological andBiomolecular Sciences, University of Milan, Via Balzaretti 9, 20133, Milan,Italy.
4
Epidemiologyand Preventive Pharmacology Centre (SEFAP), Department of Pharmacological andBiomolecular Sciences, University of Milan, Via Balzaretti 9, 20133, Milan,Italy; IRCCS MultiMedica, Via Milanese 300, 20099, Sesto S. Giovanni (MI),Italy.