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抗うつ薬による自殺と暴力(犯罪)

目的:抗うつ薬の投与開始後の自殺および暴力的な行動の発生率を調べる。方法:1997年から2015年までのデンマークのレジストリで、抗うつ薬の購入、自殺、自殺未遂、暴力犯罪の有罪判決について、997 911人の徴集兵と95794人の初回感情障害患者のコホートが追跡されました。抗うつ薬の開始または試験参加から最初の28日間、28日から365日後までの発生率を評価。結果:徴集兵の16.5%と情動障害患者の73.7%が抗うつ薬の投与を開始しました。自殺の発生率は、両方のコホートの翌年の割合と比較して、開始後最初の28日間で34倍高かった。感情障害のある未治療患者でも同様の傾向が見られましたが、抗うつ薬で治療されていない徴集兵では自殺率は低いレベルで安定していました。自殺未遂の発生率は、抗うつ薬の投与開始前後の28日間で最も高く、暴力犯罪の発生率は投与開始前後で同様でした。発生率のこれらの傾向は、抗うつ薬のクラスとは無関係でした。結論:抗うつ薬の投与開始後数週間の自殺行動の割合が高いことは、おそらく病気の重症度と気分反応の遅れを反映している。

ActaPsychiatr Scand. 2019 Sep 5. doi:10.1111/acps.13097. [Epub ahead of print]

Incidence ofsuicidal behaviour and violent crime following antidepressant medication.A Danish cohort study.

Osler M1,2, Wium-Andersen MK1, Wium-Andersen IK1,3, Gronemann FH1, Jørgensen MB3, Rozing MP2,3,4.

1

Centerfor Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospitals,Nordre Fasanvej 57, Frederiksberg, 2000 F.

2

Sectionfor Epidemiology, Department of Public Health, University of Copenhagen, ØsterFarimagsgade 5, Copenhagen, K 1014.

3

PsychiatricCentre Copenhagen dept O, Rigshospitalet, Edel Sauntes Allé 10, Copenhagen, Ø2100.

4

TheResearch Unit for General Practice and Section of General Practice, Departmentof Public Health, University of Copenhagen, Copenhagen, Denmark.

Abstract

OBJECTIVE:

To examine the incidence ofsuicidal and violent behaviour following initiation of antidepressant medication.

METHOD:

Cohorts of 997 911 conscripts and95 794 patients with a first-time affective disorder werefollowed for purchase of antidepressant medication,suicide, suicide attempts and conviction for violent crime in Danish registriesbetween 1997 through 2015. Incidence of outcomes was estimated for the first 28days, 28 to 365 days or later after initiation of antidepressants or studyentry.

RESULTS:

16.5% of conscripts and 73.7% ofpatients with affective disorders initiated antidepressant medication. Incidence of suicide was3-4 times higher during the first 28 days after initiation compared to therates in the following year in both cohorts. A similar trend was seen among theuntreated patients with affective disorders,whereas suicide incidence was stable at a low level among conscripts nottreated with antidepressants. Incidence of attempted suicide was highest duringthe 28 days before and after initiation of antidepressants, while rates ofviolent crime were similar before and after initiation. These trends inincidence were independent of class of antidepressant.

CONCLUSION:

Higher rates of suicidal behaviourin the weeks following initiation of antidepressant medicationprobably reflects disease severity and a delay in mood response. This articleis protected by copyright. All rights reserved.




by fibromyalgia11 | 2019-09-17 21:13 | 抗うつ薬
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世界標準の線維筋痛症を専門家が説明します


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