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線維筋痛症と慢性疲労症候群の病因としての神経炎症:子宮頸癌ワクチンとの関連


線維筋痛症は、疲労、自律神経障害、認知障害および睡眠障害などの慢性的な広範囲の痛みと痛みのない症状を特徴とする障害です。その病因と治療は議論の対象となっています。疾患の病因における3つのメカニズム- 自己免疫神経炎症、および小繊維神経障害役割を強調しています。これらのメカニズムは密接に関連していることが示されており(分子レベルでも)、レビューでは治療オプションの検索におけるこの関係の実装を検討しています。慢性疲労症候群にも注意を払います 、これは線維筋痛症と重複し、その病因について「自己免疫性低視床症hypothalamopathy」の概念を提案します。最後に、HPV ワクチン接種後の有害 事象の発症における神経炎症背景の基礎となる分子メカニズムを分析し、線維筋痛症の病因のモデルとして、HPV ワクチン接種後の症状の発症を悪化させる可能性のある神経炎症を示唆します(これは熱く議論されていますが)。

Int J Mol Sci. 2019 Oct 18;20(20). pii: E5164. doi:10.3390/ijms20205164.

Neuroimmunology: What Role forAutoimmunity, Neuroinflammation, and Small Fiber Neuropathy in Fibromyalgia, Chronic Fatigue Syndrome, and AdverseEvents after Human Papillomavirus Vaccination?

Ryabkova VA1, Churilov LP2,3, Shoenfeld Y4,5.

1

Laboratory of the Mosaic of Autoimmunity, Saint Petersburg StateUniversity, Saint-Petersburg 199034, Russian Federation.varvara-ryabkova@yandex.ru.

2

Laboratory of the Mosaic of Autoimmunity, Saint Petersburg StateUniversity, Saint-Petersburg 199034, Russian Federation. elpach@mail.ru.

3

Saint Petersburg Research Institute of Phthisiopulmonology;Saint-Petersburg 191036, Russian Federation. elpach@mail.ru.

4

Laboratory of the Mosaic of Autoimmunity, Saint Petersburg State University,Saint-Petersburg 199034, Russian Federation. shoenfel@post.tau.ac.il.

5

Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center,affiliated to Tel-Aviv University School of Medicine, Tel-Hashomer 52621,Israel. shoenfel@post.tau.ac.il.

Abstract

Fibromyalgia is a disorder characterized by chronic widespread pain and non-pain symptoms, such as fatigue, dysautonomia, andcognitive and sleep disturbances. Its pathogenesis and treatment continue to bethe subject of debate. We highlight the role of three mechanisms-autoimmunity,neuroinflammation, and small fiber neuropathy-in the pathogenesis of thedisease. These mechanisms are shown to be closely interlinked (also on amolecular level), and the review considers the implementation of this relationshipin the search for therapeutic options. We also pay attention to chronic fatiguesyndrome, which overlaps with fibromyalgia, andpropose a concept of "autoimmune hypothalamopathy" for itspathogenesis. Finally, we analyze the molecular mechanisms underlying theneuroinflammatory background in the development of adverse events following HPVvaccination and suggesting neuroinflammation, which could exacerbate thedevelopment of symptoms following HPV vaccination (though this is hotlydebated), as a model for fibromyalgiapathogenesis.




by fibromyalgia11 | 2019-10-23 19:18 | FMの雑感
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世界標準の線維筋痛症を専門家が説明します


by fibromyalgia11
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