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鎮痛薬の古い研究と新しい研究の比較(NNT)の際の注意点

一次的な結果として、50%の鎮痛 (さもなければ30%の鎮痛又は中等度の鎮痛)のための統合したnumberneeded to treat (NNT)を用いた. 128の結果を解析. NNTの値は、1982年から1999年の間に出版された研究における24付近から2010年以降に出版された研究では遥かに高く(有効性が低い)増加。より大規模な研究、より長期間の研究期間、そしてより多くの研究が50%又は30%の鎮痛を報告する等の、時間と共に変化したいくつかの要因が、推定した薬の効果の大きさの低下と関連. これらは、デザイン、結果および報告は、治療効果の推定の際に変化があることを意味する.これらの要因は、個々の研究データのデザインや解釈、系統的総説やメタ解析の際に重要。

Pain. 2018 Jul 12. doi:10.1097/j.pain.0000000000001340. [Epub ahead of print]

Neuropathic Pain Clinical Trials: Factors Associated with Decreases in Estimated DrugEfficacy.

Finnerup NB1, Haroutounian S2, Baron R3, Dworkin RH4, Gilron I5, Haanpaa M6, Jensen TS1, Kamerman PR7, McNicol E8, Moore A9, Raja SN10, Andersen NT11, Sena ES12, Smith BH13, Rice AS14, Attal N15.

1

DanishPain Research Center, Department of Clinical Medicine, Aarhus University andDepartment of Neurology, Aarhus University Hospital, Aarhus, Denmark.

2

Divisionof Clinical and Translational Research, Department of Anesthesiology, and PainCenter, Washington University in St. Louis School of Medicine, St Louis MO USA.

3

Divisionof Neurological Pain Research and Therapy, Department of Neurology,Universitätsklinikum Schleswig-Holstein, Campus Kiel, Kiel, Germany.

4

Departmentsof Anesthesiology and Perioperative Medicine, Neurology, and Psychiatry,University of Rochester School of Medicine and Dentistry, Rochester, New York,USA.

5

Departmentof Anesthesiology & Perioperative Medicine, Queen's University and KingstonGeneral Hospital, Kingston, Ontario, Canada.

6

IlmarinenMutual Insurance Company, Helsinki, Finland.

7

BrainFunction Research Group, Faculty of Health Sciences, University of theWitwatersrand, Johannesburg, South Africa.

8

TuftsMedical Center, Departments of Pharmacy and Anesthesiology & PerioperativeMedicine, and Tufts University School of Medicine, Boston MA, USA.

9

NuffieldDivision of Anaesthetics, Nuffield Department of Clinical Neurosciences, PainResearch, The Churchill, Oxford, UK.

10

Divisionof Pain Medicine, Department of Anesthesiology and Critical Care Medicine,Johns Hopkins University, USA.

11

NTSection for Biostatistics, Department of Public Health, Aarhus University,Aarhus, Denmark.

12

Centrefor Clinical Brain sciences, University of Edinburgh, Edinburgh, UK.

13

Divisionof Population Health Sciences, School of Medicine, University of Dundee,Ninewells Hospital and Medical School, Dundee, DD2 4BF, Scotland.

14

PainResearch, Department of Surgery and Cancer, Imperial College London, London,United Kingdom.

15

INSERMU-987, Centre d'Evaluation et de Traitement de la Douleur, Hôpital AmbroiseParé, Assistance Publique Hôpitaux de Paris, Boulogne-Billancourt, France.


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by fibromyalgia11 | 2018-07-22 08:15 | 神経障害性疼痛
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世界標準の線維筋痛症を専門家が説明します


by fibromyalgia11
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